Fertility doctors took and froze eggs from the mother, a then 29-year-old French woman, before she started chemotherapy for breast cancer, then successfully fertilised one and placed it in her womb five years later

A baby is believed to be the first in the world to be born after eggs were taken from his mother and matured in a lab before being frozen, scientists have revealed.

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They said the arrival of baby Jules is the first reported case of a baby born after immature eggs were grown outside of the mother and then thawed, fertilised and implanted years later.

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Fertility doctors took eggs from the mother, a then 29-year-old French woman, before she started chemotherapy for breast cancer.

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But there was not enough time for her to be given ovarian stimulation hormones to help her produce mature eggs that could be frozen.

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Instead, the experts removed seven immature eggs from her ovaries and used a technique called in vitro maturation (IVM) to help them to develop further in the laboratory.

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They say the case offers hope to women who would like to have children after a cancer diagnosis, but for whom ovarian stimulation is hazardous.

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The method also avoids the risk of "re-seeding the cancer", which can happen in some cancers when ovarian tissue is later transplanted back into a cancer patient.

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Until now, there have been no successful pregnancies in cancer patients after eggs that have undergone IVM and then been frozen, although some children have been born as a result of IVM followed by immediate fertilisation and transfer to the patient without freezing.

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Professor Michael Grynberg, head of the Department of Reproductive Medicine and Fertility Preservation at the Antoine Beclere University Hospital, near Paris, said he and his team are thrilled with the result.

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"We were delighted that the patient became pregnant without any difficulty and successfully delivered a healthy baby at term," he said.

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"My team and I trusted that IVM could work when ovarian stimulation was not feasible."

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He added: "This success represents a breakthrough in the field of fertility preservation."

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The case has been outlined in a letter in the cancer journal Annals of Oncology.

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After maturing, the eggs were then frozen by vitrification, which freezes the eggs very rapidly in liquid nitrogen to reduce the chances of ice crystals forming and damaging the cell.

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Five years later, when the woman had recovered from her cancer, she discovered the treatment had left her infertile.

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She and her doctors decided to use the frozen eggs, five of which were fertilised successfully after being thawed.

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One embryo was transferred to the patient's womb, and nine months later she gave birth to a healthy boy on July 6, 2019.

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Prof Grynberg said egg or embryo vitrification after ovarian stimulation is still the most established and efficient option, but that his team's success gives women another option.

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He continued: "IVM enables us to freeze eggs or embryos in urgent situations or when it would be hazardous for the patient to undergo ovarian stimulation.

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"In addition, using them is not associated with a risk of cancer recurrence.

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"We are aware that eggs matured in the lab are of lower quality when compared to those obtained after ovarian stimulation.

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"However, our success with Jules shows that this technique should be considered a viable option for female fertility preservation, ideally combined with ovarian tissue cryopreservation as well."

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in lab and frozen after mum got cancer”,”authors”:[]},”keywords”:[{“count”:2,”text”:”Fertility doctors”,”relevance”:0.645034},{“count”:1,”text”:”first reported case of a baby”,”relevance”:0.630549},{“count”:1,”text”:”arrival of baby Jules”,”relevance”:0.630196},{“count”:1,”text”:”Professor Michael Grynberg”,”relevance”:0.630073},{“count”:1,”text”:”cancer patient”,”relevance”:0.619778},{“count”:2,”text”:”breast cancer”,”relevance”:0.606491},{“count”:1,”text”:”frozen eggs”,”relevance”:0.586121},{“count”:1,”text”:”ovarian stimulation hormones”,”relevance”:0.580107},{“count”:2,”text”:”29-year-old French woman”,”relevance”:0.573784},{“count”:1,”text”:”Antoine Beclere University Hospital”,”relevance”:0.570975},{“count”:1,”text”:”cancer patients”,”relevance”:0.561964},{“count”:1,”text”:”head of the Department of Reproductive Medicine”,”relevance”:0.561238},{“count”:2,”text”:”immature eggs”,”relevance”:0.551634},{“count”:1,”text”:”efficient option”,”relevance”:0.550389},{“count”:1,”text”:”Fertility Preservation”,”relevance”:0.548156},{“count”:1,”text”:”viable option”,”relevance”:0.546883},{“count”:8,”text”:”eggs”,”relevance”:0.545556},{“count”:1,”text”:”liquid nitrogen”,”relevance”:0.543543},{“count”:1,”text”:”Prof Grynberg”,”relevance”:0.542261},{“count”:1,”text”:”baby”,”relevance”:0.541192}],”analyzed_text”:”Fertility doctors took and froze eggs from the mother, a then 29-year-old French woman, before she started chemotherapy for breast cancer, then successfully fertilised one and placed it in her womb five years later nA baby is believed to be the first in the world to be born after eggs were taken from his mother and matured in a lab before being frozen, scientists have revealed.nThey said the arrival of baby Jules is the first reported case of a baby born after immature eggs were grown outside of the mother and then thawed, fertilised and implanted years later.nFertility doctors took eggs from the mother, a then 29-year-old French woman, before she started chemotherapy for breast cancer.nBut there was not enough time for her to be given ovarian stimulation hormones to help her produce mature eggs that could be frozen.nWorld’s most fertile woman who had 44 children heartbreaking only wish for her kidsnMum, 33, describes the constant agony of living with ‘suicide disease’nInstead, the experts removed seven immature eggs from her ovaries and used a technique called in vitro maturation (IVM) to help them to develop further in the laboratory.nThey say the case offers hope to women who would like to have children after a cancer diagnosis, but for whom ovarian stimulation is hazardous.nThe method also avoids the risk of “re-seeding the cancer”, which can happen in some cancers when ovarian tissue is later transplanted back into a cancer patient.nUntil now, there have been no successful pregnancies in cancer patients after eggs that have undergone IVM and then been frozen, although some children have been born as a result of IVM followed by immediate fertilisation and transfer to the patient without freezing.nProfessor Michael Grynberg, head of the Department of Reproductive Medicine and Fertility Preservation at the Antoine Beclere University Hospital, near Paris, said he and his team are thrilled with the result. n”We were delighted that the patient became pregnant without any difficulty and successfully delivered a healthy baby at term,” he said.n”My team and I trusted that IVM could work when ovarian stimulation was not feasible.”nHe added: “This success represents a breakthrough in the field of fertility preservation.”nThe case has been outlined in a letter in the cancer journal Annals of Oncology.nAfter maturing, the eggs were then frozen by vitrification, which freezes the eggs very rapidly in liquid nitrogen to reduce the chances of ice crystals forming and damaging the cell.nFive years later, when the woman had recovered from her cancer, she discovered the treatment had left her infertile.nShe and her doctors decided to use the frozen eggs, five of which were fertilised successfully after being thawed.nOne embryo was transferred to the patient’s womb, and nine months later she gave birth to a healthy boy on July 6, 2019.nProf Grynberg said egg or embryo vitrification after ovarian stimulation is still the most established and efficient option, but that his team’s success gives women another option.nHe continued: “IVM enables us to freeze eggs or embryos in urgent situations or when it would be hazardous for the patient to undergo ovarian stimulation.n Top news stories from Mirror Online n”In addition, using them is not associated with a risk of cancer recurrence.n”We are aware that eggs matured in the lab are of lower quality when compared to those obtained after ovarian stimulation.n”However, our success with Jules shows that this technique should be considered a viable option for female fertility preservation, ideally combined with ovarian tissue 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  • NewsFirst baby in world born from eggs grown in lab and frozen after mum got cancer

    Fertility doctors took and froze eggs from the mother, a then 29-year-old French woman, before she started chemotherapy for breast cancer, then successfully fertilised one and placed it in her womb five years later

      Fertility doctors took and froze eggs from the mum, then successfully fertilised one and placed it in her womb five years later (Image: Getty Images)

      A baby is believed to be the first in the world to be born after eggs were taken from his mother and matured in a lab before being frozen, scientists have revealed.

      They said the arrival of baby Jules is the first reported case of a baby born after immature eggs were grown outside of the mother and then thawed, fertilised and implanted years later.

      Fertility doctors took eggs from the mother, a then 29-year-old French woman, before she started chemotherapy for breast cancer.

      But there was not enough time for her to be given ovarian stimulation hormones to help her produce mature eggs that could be frozen.

      Until now, there have been no successful pregnancies in cancer patients after eggs that have undergone IVM
      (Image: Getty Images)

      • World's most fertile woman who had 44 children heartbreaking only wish for her kids

      • Mum, 33, describes the constant agony of living with 'suicide disease'

      Instead, the experts removed seven immature eggs from her ovaries and used a technique called in vitro maturation (IVM) to help them to develop further in the laboratory.

      They say the case offers hope to women who would like to have children after a cancer diagnosis, but for whom ovarian stimulation is hazardous.

      The method also avoids the risk of "re-seeding the cancer", which can happen in some cancers when ovarian tissue is later transplanted back into a cancer patient.

      Doctors say the case offers hope to women who would like to have children after a cancer diagnosis, but for whom ovarian stimulation is hazardous
      (Image: Getty Images)

      Until now, there have been no successful pregnancies in cancer patients after eggs that have undergone IVM and then been frozen, although some children have been born as a result of IVM followed by immediate fertilisation and transfer to the patient without freezing.

      Professor Michael Grynberg, head of the Department of Reproductive Medicine and Fertility Preservation at the Antoine Beclere University Hospital, near Paris, said he and his team are thrilled with the result.

      "We were delighted that the patient became pregnant without any difficulty and successfully delivered a healthy baby at term," he said.

      Experts removed seven immature eggs from the mum's ovaries and used IVM to help them develop further in the lab
      (Image: Getty Images)

      "My team and I trusted that IVM could work when ovarian stimulation was not feasible."

      He added: "This success represents a breakthrough in the field of fertility preservation."

      The case has been outlined in a letter in the cancer journal Annals of Oncology.

      After maturing, the eggs were then frozen by vitrification, which freezes the eggs very rapidly in liquid nitrogen to reduce the chances of ice crystals forming and damaging the cell.

      Baby Jules is the first reported case of a baby born after immature eggs were grown outside of the mother and then thawed, fertilised and implanted
      (Image: Getty Images)

      Five years later, when the woman had recovered from her cancer, she discovered the treatment had left her infertile.

      She and her doctors decided to use the frozen eggs, five of which were fertilised successfully after being thawed.

      One embryo was transferred to the patient's womb, and nine months later she gave birth to a healthy boy on July 6, 2019.

      Prof Grynberg said egg or embryo vitrification after ovarian stimulation is still the most established and efficient option, but that his team's success gives women another option.

      He continued: "IVM enables us to freeze eggs or embryos in urgent situations or when it would be hazardous for the patient to undergo ovarian stimulation.

      "In addition, using them is not associated with a risk of cancer recurrence.

      "We are aware that eggs matured in the lab are of lower quality when compared to those obtained after ovarian stimulation.

      "However, our success with Jules shows that this technique should be considered a viable option for female fertility preservation, ideally combined with ovarian tissue cryopreservation as well."

      Sourse: www.mirror.co.uk

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