This image shows one of the new laboratory models, known as PGA, at day 18 of growth. PGA is composed of two distinct cell populations (purple, extraembryonic mesoderm; yellow, amniotic endoderm). (Image credit: Gharibi, B. (2025). Cell.)
Researchers have created a new laboratory model derived from stem cells that mimics the human amniotic sac in the first two to four weeks after fertilization.
The structure, which the researchers call the most advanced and mature amniotic model ever created, could provide new insights into human development and lead to the development of cell products for medical procedures ranging from burn treatment to corneal repair, the team reported in a study published July 10 in the journal Cell.
The developing human embryo does not exist in isolation. “Supportive tissues such as the placenta and amniotic sac develop alongside the embryo and play an important role in its growth and survival,” said study co-author Silvia Santos, a team leader at the Francis Crick Institute in London.
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