Scientists have created a molecular sensor that, when exposed to an influenza virus enzyme, releases a volatile odorant with a distinct thyme scent. The technology is described in the journal ACS Central Science.
The sensor is based on a molecule specifically tuned to the viral enzyme neuraminidase. When the virus is active, it breaks down this molecule and releases thymol, a compound in thyme with a strong, grassy odor that is easily detected by the nose. This way, in the future, an infected person could detect this odor, perhaps integrated into chewing gum or candy, without having to resort to expensive tests.
In laboratory tests, the sensor worked in saliva samples and nasal washes from flu patients, with odor appearing within minutes. The sensor was safe for human cells and mouse tissue explants (e.g., trachea).
The developers say this approach has the potential to become the first simple home screening tool. It could detect viral activity in the early stages of infection, which is important for preventing the spread, as this is when the risk of transmission is particularly high. An international patent application has been filed for the technology.
